Endocrine Abstracts

Subclinical hypothyroidism (SHypo) is characterized by elevated serum TSH and thyroid hormone levels at the lower limit but within their respective reference range.It is necessary to distinguish between patients with mildly increased serum TSH levels (5–9 mU/L) and patients with more severely increased serum TSH levels (10 mU/l or higher). About 75% of all SHypo patients have mild disease.The high prevalence (between 4 and 20%...

The cardiovascular system is one of the major targets of thyroid hormone action, sensitive enough to detect the effects of thyroid hormone excess or deficiency at tissue level. Triiodothyronine (T3) acts on the heart and vascular system by classic genomic as well as non-genomic mechanisms and influences heart rate, systolic and diastolic function and systemic vascular resistance thereby affecting cardiac performance. In human short-term overt hyperthyroidism, the increase in l...

The objective of our study was to evaluate the potential benefit of short-term combined treatment with LT4plusLT3 in patients with persistent hypothyroidism and malabsorption. We report ten cases of patients with hypothyroidism secondary to total thyroidectomy, in which high doses of L-T4 (2,7-3.5 mcg/kg/die) were not adequate to normalize thyroid function. TSH was persistently high (from 10 to 100 mU/L) with low serum levels of thyroid hormones.<p class="ab...